Accessing C2-Functionalized 1,3-(Benz)azoles through Transition Metal-Catalyzed C−H Activation

Abstract

The skeletal presence of 1,3-azoles in a variety of bioactive natural products, pharmacophores, and organic materials demands the derivatization of such heteroarenes regioselectively. Plenty of cross-coupling as well as cyclocondensation reactions have been performed to build up these skeletons but remained commercially unrealizable. A couple of severe drawbacks are faced by these traditional protocols that require a more straightforward strategy to obviate them. Transition metal-catalyzed c−h functionalization has emerged as a superior alternative in that context. 1,3-azoles and their benzo counterparts have been extensively functionalized exploiting both noble and earth-abundant transition metals. Lately, c-2 functionalization have gained much traction due to the ease of attaining high regioselectivity and installation of synthetically manipulative functionalities. This critical review presents a bird‘s eye view of all major c-2 functionalization of (benz)azoles catalyzed by a diverse set of metals performed over the past 15 years. © 2021 wiley-vch gmbh