Abstract:
Introduction: the challenges posed by emergent strains of sars-cov-2 need to be tackled by contemporary scientific approaches, with proteomics playing a significant role. Areas covered: in this review, we provide a brief synthesis of the impact of proteomics technologies in elucidating disease pathogenesis and classifiers for the prognosis of covid-19 and propose proteomics methodologies that could play a crucial role in understanding emerging variants and their altered disease pathology. From aiding the design of novel drug candidates to facilitating the identification of t cell vaccine targets, we have discussed the impact of proteomics methods in covid-19 research. Techniques varied as mass spectrometry, single-cell proteomics, multiplexed elisa arrays, high-density proteome arrays, surface plasmon resonance, immunopeptidomics, and in silico docking studies that have helped augment the fight against existing diseases were useful in preparing us to tackle sars-cov-2 variants. We also propose an action plan for a pipeline to combat emerging pandemics using proteomics technology by adopting uniform standard operating procedures and unified data analysis paradigms. Expert opinion: the knowledge about the use of diverse proteomics approaches for covid-19 investigation will provide a framework for future basic research, better infectious disease prevention strategies, improved diagnostics, and targeted therapeutics. © 2022 informa uk limited, trading as taylor & francis group.