Abstract:
In this review, we have abstracted the various syntheses of both enantiomers of muricatacin (a member of a bigger class of acetogenins, ACGs), over the last decade (2010-2020). Developments in the synthesis of various epimers, homologues, oxa-analogues, delta-lactones, and the furofuranone analogues are also enfolded in this review. Most of the synthesis involve chiral pool and catalytic enantioselective approaches, while a few are hinged on the use of chiral auxiliary and resolution methods. Muricatacin with orthogonally differentiated two oxy-functions also serve as a start point in the synthesis of higher molecules of the acetogenin family, for example,cis-solamins, and these have also been covered herein.