| Title: | N-Alkylation of diethyl acetamidomalonate: synthesis of constrained amino acid derivatives by ring-closing metathesis |
| Author: | KOTHA, SAMBASIVARAO; SINGH, KULDEEP |
| Abstract: | An efficient method for N-alkylation of diethyl acetamidomalonate (DEAM) is reported. C-Alkenylation was achieved by treating the N-alkenylated DEAM with various electrophiles in the presence of Cs2CO3. RCM reactions of C- and N-alkenylated products gave cyclic amino acid derivatives in good yields. |
| URI: |
http://dx.doi.org/10.1016/j.tetlet.2004.11.013
http://hdl.handle.net/10054/878 http://dspace.library.iitb.ac.in/xmlui/handle/10054/878 |
| Date: | 2004 |
| Files | Size | Format | View |
|---|---|---|---|
| 5290-2.pdf | 146.5Kb |
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