Nano-in-micro alginate based hybrid particles

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Nano-in-micro alginate based hybrid particles

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Title: Nano-in-micro alginate based hybrid particles
Author: JOSHI, A; KEERTHIPRASAD, R; JAYANT, RD; SRIVASTAVA, R
Abstract: Novel template containing 'Nanoparticles (gelatin and CaCO(3)) embedded in Microspheres' ('Nano-in-micro') was developed using atomization. Dexamethasone loaded gelatin nanoparticles, fluorescein isothiocyanate-dextran (FITC-dex) loaded CaCO(3) nanoparticles and alginate based 'Nano-in-micro' system were prepared and characterized using optical microscopy, SEM, TEM. DLS, zeta potential, CLSM and FTIR. The results indicate that spherical, non-aggregating, 'nano-in-micro' particles (5-60 mu m) can be prepared using atomization technique. Dexamethasone release from gelatin nanoparticles and 'nano-in-micro' systems indicated a decrease in burst release in the order: uncoated (24%) > coated (18%) > 'nano-in-micro' system (1:4 ratio) (17%). The sustained release decreased in order of 'nano-in-micro' (1:4 ratio) (14 days) > coated nanoparticles (9 days)> uncoated nanoparticles (4 days) for 95% drug release. FITC-dex loading and release from CaCO(3) nanoparticles were found to be molecular weight dependent. Thus, 'nano-in-micro' systems show possibility for use as drug release vehicles, biosensors and multifunctional systems.
URI: http://dx.doi.org/10.1016/j.carbpol.2010.03.050
http://dspace.library.iitb.ac.in/xmlui/handle/10054/6165
http://hdl.handle.net/10054/6165
Date: 2010


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