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dc.contributor.authorDEY, Men_US
dc.contributor.authorALI, Aen_US
dc.contributor.authorACHARYA, Aen_US
dc.contributor.authorRAO, CPen_US
dc.date.accessioned2011-07-20T11:09:41Zen_US
dc.date.accessioned2011-12-26T12:51:27Zen_US
dc.date.accessioned2011-12-27T05:36:34Z
dc.date.available2011-07-20T11:09:41Zen_US
dc.date.available2011-12-26T12:51:27Zen_US
dc.date.available2011-12-27T05:36:34Z
dc.date.issued2010en_US
dc.identifier.citationINDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 49(8), 1098-1108en_US
dc.identifier.issn0376-4699en_US
dc.identifier.urihttp://dspace.library.iitb.ac.in/xmlui/handle/10054/5452en_US
dc.identifier.urihttp://hdl.handle.net/10054/5452
dc.description.abstractNovel double-armed peptido-conjugates of calix[4]arene have been developed on the lower rim of the macrocycle. The functional group pendants exhibit conformational bend through the involvement of 11-atom N-H center dot center dot center dot O hydrogen bond inscribed in a 14-atom O-H center dot center dot center dot O interaction. As a result, only the terminal -COOR and -COOH groups are exposed to the environment, but not the amide moiety. The cone-conformation of the calix[4]arene is further stabilized through the O-H center dot center dot center dot O interactions at the lower rim. In effect, the conjugates exhibit a binding core at the lower rim along with hydrophobic cavity formed by the enclosure of arene moieties. Conformational mobility induced by the replacement of lower rim phenolic-OH by -OCH(3) has also been demonstrated by variable temperature NMR studies in case of the corresponding - OCH(3) derivatives. Differential receptor binding characteristics of these conjugates towards phosphate are demonstrated using absorption spectroscopy. The negatively charged phosphate group is received preferentially by the carboxylic terminal over the ester terminal conjugate.en_US
dc.language.isoenen_US
dc.publisherCOUNCIL SCIENTIFIC & INDUSTRIAL RESen_US
dc.subjectAmino-Aciden_US
dc.subjectCalixarenesen_US
dc.subjectComplexesen_US
dc.subjectRimen_US
dc.subject.otherPeptido-Conjugates Of Calix[4]Areneen_US
dc.subject.otherHmqcen_US
dc.subject.otherBinding Coreen_US
dc.subject.otherConformational Mobilityen_US
dc.subject.otherPhosphate Bindingen_US
dc.title1,3-Di-peptido-conjugates of calix[4]arene and its di-OCH(3) derivatives: Synthesis, characterization and phosphate recognitionen_US
dc.typeArticleen_US


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