1,3-Di-peptido-conjugates of calix[4]arene and its di-OCH(3) derivatives: Synthesis, characterization and phosphate recognition

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1,3-Di-peptido-conjugates of calix[4]arene and its di-OCH(3) derivatives: Synthesis, characterization and phosphate recognition

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dc.contributor.author DEY, M en_US
dc.contributor.author ALI, A en_US
dc.contributor.author ACHARYA, A en_US
dc.contributor.author RAO, CP en_US
dc.date.accessioned 2011-07-20T11:09:41Z en_US
dc.date.accessioned 2011-12-26T12:51:27Z en_US
dc.date.accessioned 2011-12-27T05:36:34Z
dc.date.available 2011-07-20T11:09:41Z en_US
dc.date.available 2011-12-26T12:51:27Z en_US
dc.date.available 2011-12-27T05:36:34Z
dc.date.issued 2010 en_US
dc.identifier.citation INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 49(8), 1098-1108 en_US
dc.identifier.issn 0376-4699 en_US
dc.identifier.uri http://dspace.library.iitb.ac.in/xmlui/handle/10054/5452 en_US
dc.identifier.uri http://hdl.handle.net/10054/5452
dc.description.abstract Novel double-armed peptido-conjugates of calix[4]arene have been developed on the lower rim of the macrocycle. The functional group pendants exhibit conformational bend through the involvement of 11-atom N-H center dot center dot center dot O hydrogen bond inscribed in a 14-atom O-H center dot center dot center dot O interaction. As a result, only the terminal -COOR and -COOH groups are exposed to the environment, but not the amide moiety. The cone-conformation of the calix[4]arene is further stabilized through the O-H center dot center dot center dot O interactions at the lower rim. In effect, the conjugates exhibit a binding core at the lower rim along with hydrophobic cavity formed by the enclosure of arene moieties. Conformational mobility induced by the replacement of lower rim phenolic-OH by -OCH(3) has also been demonstrated by variable temperature NMR studies in case of the corresponding - OCH(3) derivatives. Differential receptor binding characteristics of these conjugates towards phosphate are demonstrated using absorption spectroscopy. The negatively charged phosphate group is received preferentially by the carboxylic terminal over the ester terminal conjugate. en_US
dc.language.iso en en_US
dc.publisher COUNCIL SCIENTIFIC & INDUSTRIAL RES en_US
dc.subject amino-acid en_US
dc.subject calixarenes en_US
dc.subject complexes en_US
dc.subject rim en_US
dc.subject.other peptido-conjugates of calix[4]arene en_US
dc.subject.other hmqc en_US
dc.subject.other binding core en_US
dc.subject.other conformational mobility en_US
dc.subject.other phosphate binding en_US
dc.title 1,3-Di-peptido-conjugates of calix[4]arene and its di-OCH(3) derivatives: Synthesis, characterization and phosphate recognition en_US
dc.type Article en_US


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