Water-soluble Tc-99m-labeled dendritic novel porphyrins tumor imaging and diagnosis

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Water-soluble Tc-99m-labeled dendritic novel porphyrins tumor imaging and diagnosis

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Title: Water-soluble Tc-99m-labeled dendritic novel porphyrins tumor imaging and diagnosis
Author: SUBBARAYAN, M; SHETTY, SJ; SRIVASTAVA, TS; NORONHA, OPD; SAMUEL, AM; MUKHTAR, H
Abstract: We have synthesized two water soluble dendritic porphyrins, termed DP1 and DP2 and have successfully radiolabeIed them with Tc-99m. These Tc-99m-labeled porphyrins were administered to C-6-glioma tumor bearing Wistar rats and scintiimaging and biodistribution studies were carried out. Tumor to muscle ratios of DP1 and DP2 were 8.0 and 9.7, respectively. These molecules may have potential for tumor imaging and diagnosis and may even prove useful as photosensitizers in photodynamic therapy applications.
URI: http://dx.doi.org/10.1006/bbrc.2001.4289
http://dspace.library.iitb.ac.in/xmlui/handle/10054/3336
http://hdl.handle.net/10054/3336
Date: 2001


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