Yagyopathy versus oral and IV drug administration: Evaluation for pulmonary tuberculosis using compartment modeling

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Yagyopathy versus oral and IV drug administration: Evaluation for pulmonary tuberculosis using compartment modeling

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dc.contributor.author JOSHI, RR en_US
dc.contributor.author RAGHUVANSHI, M en_US
dc.contributor.author PANDYA, P en_US
dc.date.accessioned 2011-09-02T03:19:50Z en_US
dc.date.accessioned 2011-12-26T12:59:56Z en_US
dc.date.accessioned 2011-12-27T05:53:08Z
dc.date.available 2011-09-02T03:19:50Z en_US
dc.date.available 2011-12-26T12:59:56Z en_US
dc.date.available 2011-12-27T05:53:08Z
dc.date.issued 2006 en_US
dc.identifier.citation JOURNAL OF BIOLOGICAL SYSTEMS, 14(3), 463-489 en_US
dc.identifier.issn 0218-3390 en_US
dc.identifier.uri http://dx.doi.org/10.1142/S0218339006001891 en_US
dc.identifier.uri http://dspace.library.iitb.ac.in/xmlui/handle/10054/12951 en_US
dc.identifier.uri http://hdl.handle.net/10054/12951
dc.description.abstract With pulmonary drug administration gaining more and more importance, there is an obvious need for improvement in the existing methods and search for the newer ones. We have carried out the first ever study on the potentials of yagyopathy in this regard. While introducing this new mode of pulmonary drug administration, we also highlight some preliminary clinical and empirical results on drug inhalation characterization of yagyopathy that indicate its effectiveness in the treatment of pulmonary tuberculosis and thus motivate the present study. We construct mathematical models to evaluate the efficacy of this method of herbal cure vis-a-vis the common modes of oral and intravenous medication. The models are analyzed mathematically for the availability of the drug and other important pharmacokinetic features for the case when the site of infection and hence of desired activation is located in the lungs. Computer simulation experiments and validation are also carried out using available data from relevant empirical studies. The results further support significant potential of yagyopathy especially in terms of higher lung deposits, (bio) availability and residence time. The scope of yagyopathy and related research directions are discussed. en_US
dc.language.iso en en_US
dc.publisher WORLD SCIENTIFIC PUBL CO PTE LTD en_US
dc.subject inhalation en_US
dc.subject bioavailability en_US
dc.subject deposition en_US
dc.subject absorption en_US
dc.subject.other yagya (homa) en_US
dc.subject.other pulmonary drug administration en_US
dc.subject.other mathematical modeling for pharmacokinetic simulation en_US
dc.subject.other pulmonary tuberculosis en_US
dc.title Yagyopathy versus oral and IV drug administration: Evaluation for pulmonary tuberculosis using compartment modeling en_US
dc.type Article en_US


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