Enantioselective Synthesis of Phenyl-ethanolamines Through Application of Chiral Sulfoxide

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Enantioselective Synthesis of Phenyl-ethanolamines Through Application of Chiral Sulfoxide

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Title: Enantioselective Synthesis of Phenyl-ethanolamines Through Application of Chiral Sulfoxide
Author: SIVAKUMAR, AV; LAHOTI, AM; BHAT, SV
Abstract: Efficient enantioselective synthesis of (R)- and (S)-enantiomers of 2-(tert-butylamino)-1-(p-methoxyphenyl)-ethanol has been achieved in high enantiomeric excess by using asymmetric sulfoxide as a chiral auxiliary. The present synthetic approach was further extended to the asymmetric synthesis of (R)-salbutamol.
URI: http://dx.doi.org/10.1080/00397910902765578
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12402
http://hdl.handle.net/10054/12402
Date: 2009


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