SYNTHESIS OF 2'-(3-ALPHA-BENZYLOXY-24-NORCHOLAN-23-YL)-2',4',4'-TRIMETHYL-4',5'-DIHYDROOXAZOLINE-N-OXYL - A NEW POTENTIAL SPIN PROBE FOR BIOMEMBRANES

DSpace/Manakin Repository

SYNTHESIS OF 2'-(3-ALPHA-BENZYLOXY-24-NORCHOLAN-23-YL)-2',4',4'-TRIMETHYL-4',5'-DIHYDROOXAZOLINE-N-OXYL - A NEW POTENTIAL SPIN PROBE FOR BIOMEMBRANES

Show full item record

Title: SYNTHESIS OF 2'-(3-ALPHA-BENZYLOXY-24-NORCHOLAN-23-YL)-2',4',4'-TRIMETHYL-4',5'-DIHYDROOXAZOLINE-N-OXYL - A NEW POTENTIAL SPIN PROBE FOR BIOMEMBRANES
Author: BANERJEE, S; DESAI, UR; TRIVEDI, GK
Abstract: The synthesis of a new steroidal nitroxide, viz. 2'-(3-alpha-benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'-dihydrooxazoline-N-oxyl 7, a potential spin probe for biomembranes is described. The title compound in improved yield could be obtained by a direct Grignard reaction on the oxaziridine 4. This effected a one-step reduction in the overall synthetic sequence. The methodology of the Grignard reaction on the oxaziridine to yield the nitroxide is reported for the first time. In dilute solutions, the isotropic ESR parameters for 7 have been measured.
URI: http://dx.doi.org/10.1016/S0040-4020(01)80586-X
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11419
http://hdl.handle.net/10054/11419
Date: 1992


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show full item record

Search DSpace


Advanced Search

Browse

My Account