1-[2-Hydroxy-3-octadecan-1'-oate]propyl-2 '',2 '',5 '',5 ''-tetramethyl pyrolidine-N-oxyl-3 ''-carboxylate as a potential spin probe for membrane structure studies

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1-[2-Hydroxy-3-octadecan-1'-oate]propyl-2 '',2 '',5 '',5 ''-tetramethyl pyrolidine-N-oxyl-3 ''-carboxylate as a potential spin probe for membrane structure studies

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dc.contributor.author KATOCH, R en_US
dc.contributor.author TRIVEDI, GK en_US
dc.contributor.author PHADKE, RS en_US
dc.date.accessioned 2011-08-22T08:30:06Z en_US
dc.date.accessioned 2011-12-26T12:56:16Z en_US
dc.date.accessioned 2011-12-27T05:44:43Z
dc.date.available 2011-08-22T08:30:06Z en_US
dc.date.available 2011-12-26T12:56:16Z en_US
dc.date.available 2011-12-27T05:44:43Z
dc.date.issued 1999 en_US
dc.identifier.citation BIOORGANIC & MEDICINAL CHEMISTRY, 7(12), 2753-2758 en_US
dc.identifier.issn 0968-0896 en_US
dc.identifier.uri http://dx.doi.org/10.1016/S0968-0896(99)00216-3 en_US
dc.identifier.uri http://dspace.library.iitb.ac.in/xmlui/handle/10054/10375 en_US
dc.identifier.uri http://hdl.handle.net/10054/10375
dc.description.abstract The synthesis of a new minimum steric perturbing proxyl nitroxide, which is a derivative of glycerol and contains a stearic acid moiety, has been carried out. Its localization in model membrane L-alpha-dipalmitoyl phosphatidyl choline (DPPC) was ascertained with the help of ESR, DSC, H-1 and P-31 NMR techniques. The nitroxide was used for detecting the changes in the phase transition temperature of the model membranes in the presence and absence of drugs. The permeation of the vasodilating drug epinephrine has also been studied using this spin label. The results prove the potential applicability of the new spin probe in the spin labeling of biomembranes. (C) 1999 . . en_US
dc.language.iso en en_US
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD en_US
dc.subject model membranes en_US
dc.subject chemistry en_US
dc.subject 2'-(3-alpha-benzyloxy-24-norcholan-23-yl)-2',4',4'-trimethyl-4',5'-dihydrooxazo. en_US
dc.subject nitroxides en_US
dc.subject.other 1-[2-hydroxy-3-octadecan-1 '-oate]propyl-2 '',2 '',5 '',5 '-tetramethyl en_US
dc.subject.other pyrolidine-n-oxyl-3 ''-carboxylate en_US
dc.subject.other proxyl stearate en_US
dc.subject.other spin label en_US
dc.subject.other model membrane en_US
dc.subject.other phase transition en_US
dc.title 1-[2-Hydroxy-3-octadecan-1'-oate]propyl-2 '',2 '',5 '',5 ''-tetramethyl pyrolidine-N-oxyl-3 ''-carboxylate as a potential spin probe for membrane structure studies en_US
dc.type Article en_US


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