Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/xmlui/handle/123456789/19621
Title: A concise synthesis of (4R,5R)-(-)-muricatacin and (4R,5R)-L-(-)-factor from D-glucono-delta-lactone
Authors: CHAUDHARI, DA
INGLE, AB
FERNANDES, RA
Keywords: Chemoselective Cross-Metathesis
Hydroxy-Gamma-Lactones
Hagens Gland Lactones
Enantioselective Synthesis
Enantiospecific Synthesis
Stereoselective-Synthesis
Proposed Autoregulators
Streptomyces-Griseus
Asymmetric-Synthesis
Organic-Synthesis
Issue Date: 2016
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: TETRAHEDRON-ASYMMETRY,27(42796)114-117
Abstract: A concise seven-step synthesis of (4R,5R)-(-)-muricatacin and (4R,5R)-L-(-)-factor from inexpensive, commercially available D-glucono-delta-lactone has been accomplished. The keys steps involve a one-pot conversion of the latter to gamma-vinyl-gamma-lactone, cross-metathesis and Wittig olefination. This strategy has potential for the synthesis of analogs by changing the alkyl side chain by Wittig olefination. (C) 2016 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.tetasy.2016.01.003
http://localhost:8080/xmlui/handle/123456789/19621
ISSN: 0957-4166
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