Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/xmlui/handle/123456789/19441
Title: Thermoresponsive polymeric gel as an on-demand transdermal drug delivery system for pain management
Authors: INDULEKHA, S
ARUNKUMAR, P
BAHADUR, D
SRIVASTAVA, R
Keywords: Biomedical Applications
N-Vinylcaprolactam
Aqueous-Solution
Human Plasma
Poly(N-Vinylcaprolactam)
Etoricoxib
Microgels
Behavior
Poly(N-Isopropylacrylamide)
Particles
Issue Date: 2016
Publisher: ELSEVIER SCIENCE BV
Citation: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,62,113-122
Abstract: The main aim of this work is to design a heat triggered transdermal drug delivery system (TDDS) using a thermoresponsive polymer, poly (N-vinyl caprolactam) [PNVCL] based gel, where in patients can themselves administer a pulse of drug on mere application of heat pad over the TDDS, whenever pain is experienced. The phase transition temperature of PNVCL was tuned to 35 degrees C by grafting it onto a pH sensitive biopolymer, Chitosan, to synthesize Chitosan-g-PNVCL (CP) co-polymer which render the gel both thermo- and pH-responsive property. The application of triggered delivery was explored"by loading acetamidophenol (a model hydrophilic drug) and etoricoxib (a model hydrophobic drug). In vitro drug release experiments were performed at three different temperatures (25, 32 and 39 degrees C) at two different pH (5.5 and 7) to study its drug release with response to temperature and pH. Drug release profiles obtained were found to have enhanced release for both the drugs respectively at 39 degrees C (above LCST) and pH 5.5 when compared to other release conditions. In vitro skin permeation of both the drugs performed in rat abdominal skin using Franz diffusion cell showed enhanced drug release when the skin was subjected to higher temperature (39 degrees C). Moreover, it was also found that skin permeation for hydrophobic drug was better than that of hydrophilic drug. The in vivo biocompatibility studies of the CP gel in rat skin proved that the gel is biocompatible. The results obtained demonstrated the potential use of the thermoresponsive CP gel as an on-demand localized drug delivery system. (C) 2016 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.msec.2016.01.021
http://localhost:8080/xmlui/handle/123456789/19441
ISSN: 0928-4931
1873-0191
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