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Title: Numerical investigation of the influence of pulsatile blood flow on temperature distribution within the body of laser-irradiated biological tissue phantoms
Authors: KUMAR, S
Keywords: Transient Radiative-Transfer
Light-Pulse Transport
Phase-Lag Model
Transfer Equation
Thermal Therapy
Large Vessels
Participating Medium
Absorbing Media
Issue Date: 2016
Abstract: The present work is concerned with the numerical investigation of the effects of pulsatile nature of blood flow in large size blood vessels on temperature distribution in laser-irradiated biological tissue phantoms. Phenomenon of light propagation through the tissue-blood vessel domain is modelled by transient radiative transport equation (RTE). Discrete ordinate method has been employed to solve transient form of RTE. In order to determine the temperature distribution inside the tissue-blood vessel domain, the solution of RTE has been coupled with the energy equation. Pulsatile nature of velocity profile has been employed at the inlet of the blood vessel. Navier-Stokes equations have been solved for determining the velocity field required to understand the effect of pulsatile blood flow on the temperature distribution. Relative influence of various parameters such as heart beat rate, time-averaged blood inlet velocity and size of the blood vessel on temperature distribution within the blood vessel has been presented. The numerical code developed as part of the present study has first been verified against the results available in the literature for the same operating parameters. Both homogenous as well as tissue phantoms embedded with optical inhomogeneities of different contrast levels have been considered. Results of the study clearly reveal the strong influence of pulsatile nature of blood flow on the resultant temperature distribution in the surrounding tissue region. The increase in temperature due to laser-irradiation is found to be relatively lesser in the presence of blood flow due to its convective cooling effects as compared to the rise in temperature achieved in the tissue phantom without blood vessels. (C) 2015 Elsevier Ltd. All rights reserved.
ISSN: 0017-9310
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