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|Title:||Reengineering a type II beta-turn as a potential helix nucleator-NMR characterization of Boc-Ala-Val-Pro-(D) Asp-Leu-Leu-NHMe|
|Publisher:||ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI|
|Citation:||PHYSICA MEDICA, 16(1), 7-11|
|Abstract:||A stereochemically constrained type II beta-turn is reengineered over two steps into a potential helix nucleator. NMR studies in DMSO establish that the hexapeptide Boc-Alal-Val2-Pro3-(D)Asp4-Leu5-Leu6-NHMe is a type II beta-turn at Pro3-(D)Asp4 with a conformation nucleating II-bond between Asp4 carboxylate and Leu6 NH, to which is attributable a type I/III beta-turn at Leu5-Leu6-NHMe potentially capable of serving as a helix template.|
|Appears in Collections:||Article|
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