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| Title: | Reengineering a type II beta-turn as a potential helix nucleator-NMR characterization of Boc-Ala-Val-Pro-(D) Asp-Leu-Leu-NHMe |
| Authors: | RAJU, EB
DHANASEKARAN, M
DURANI, S
SRIVASTAVA, S |
| Keywords: | proteins
peptide
conformation
spectra
design
model
water |
| Issue Date: | 2000 |
| Publisher: | ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI |
| Citation: | PHYSICA MEDICA, 16(1), 7-11 |
| Abstract: | A stereochemically constrained type II beta-turn is reengineered over two steps into a potential helix nucleator. NMR studies in DMSO establish that the hexapeptide Boc-Alal-Val2-Pro3-(D)Asp4-Leu5-Leu6-NHMe is a type II beta-turn at Pro3-(D)Asp4 with a conformation nucleating II-bond between Asp4 carboxylate and Leu6 NH, to which is attributable a type I/III beta-turn at Leu5-Leu6-NHMe potentially capable of serving as a helix template. |
| URI: | http://dspace.library.iitb.ac.in/xmlui/handle/10054/9281
http://hdl.handle.net/10054/9281 |
| ISSN: | 1120-1797 |
| Appears in Collections: | Article
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