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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/906

Title: Robust global sensitivity in multiple enzyme cascade system explains how the downstream cascade structure may remain unaffected by cross-talk
Authors: MUTALIK, VIVEK K
SINGH, ADITYA P
EDWARDS, JEREMY S
VENKATESH, KV
Keywords: signal amplification
ultrasensitivity
robustness
mitogen activated protein kinase
enzyme cascade
crosstalk
Issue Date: 2004
Publisher: Elsevier
Citation: FEBS Letters 558(1-3), 79-84
Abstract: A steady-state framework was applied to the ubiquitous tricyclic enzyme cascade structure, as seen in the mitogen-activated protein (MAP) kinase system, to analyze the effect of upstream kinase concentrations on final output response. The results suggest that signal amplification achieved by the cascade structure ensured that the modifying enzymes at various steps of the cascade were nearly saturated. Thus, there was no change in the response sensitivity with increasing upstream kinase concentration. Analysis was also extended to branching of a signaling pathway as an example of cross-talk. It was observed that the cascade structure confers a larger share of the signal transduction properties to its last kinase. This phenomenon in enzyme cascades may explain how the response of the terminal MAP kinase is unaffected by cross-talk of upstream kinases.
URI: http://dx.doi.org/10.1016/S0014-5793(04)00021-3
http://hdl.handle.net/10054/906
http://dspace.library.iitb.ac.in/xmlui/handle/10054/906
ISSN: 0014-5793
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