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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/878

Title: N-Alkylation of diethyl acetamidomalonate: synthesis of constrained amino acid derivatives by ring-closing metathesis
Authors: KOTHA, SAMBASIVARAO
SINGH, KULDEEP
Keywords: chromatography
derivatives
amino acids
synthesis
Issue Date: 2004
Publisher: Elsevier
Citation: Tetrahedron Letters 45(52), 9607-9610
Abstract: An efficient method for N-alkylation of diethyl acetamidomalonate (DEAM) is reported. C-Alkenylation was achieved by treating the N-alkenylated DEAM with various electrophiles in the presence of Cs2CO3. RCM reactions of C- and N-alkenylated products gave cyclic amino acid derivatives in good yields.
URI: http://dx.doi.org/10.1016/j.tetlet.2004.11.013
http://hdl.handle.net/10054/878
http://dspace.library.iitb.ac.in/xmlui/handle/10054/878
ISSN: 0040-4039
Appears in Collections:Article

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