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|Title:||Thiol peroxidase-like activity of some intramolecularly coordinated diorganyl diselenides|
|Keywords:||Synthetic Organoselenium Compounds|
|Publisher:||INDIAN ACADEMY SCIENCES|
|Citation:||JOURNAL OF CHEMICAL SCIENCES, 117(6), 621-628|
|Abstract:||Several new diaryl diselenides having intramolecular coordinating groups have been synthesized by ortho-lithiation/Na2Se2 routes in good yield. Bis[2-(N-phenylferrocenecarboxamide)] diselenide (10), bis[2-(N-tert-butylferrocenecarboxamide)] diselenide (11), (S)(S)-bis[2(-N-phenethylferocene-carboxamide)] diselenide (12) were synthesized by the ortho-lithiation route. Bis[2-(N,N-dimethylaminomethyinaphthyl)] diselenide (13) was synthesized by lithium/bromide exchange reaction whereas bis(2,4-dinitrophenyl) diselenide (14) was prepared by the reaction of disodium diselenide with 2,4dinitro-1-chlorobenzene. Thiol peroxidase-like activities of the diorganodiselenides have been evaluated by using H2O2 as substrate and PhSH as cosubstrate. Diselerrides (13) and (14) with dimethylaminomethyl- or nitro-donor groups in close proximity to selenium, show much better thiol peroxidase-like activities compared to diselenides 10-12 with amide donor groups. Cyclic voltammetry study of diselenides 10-12 derived from redox-active ferrocenamide has been carried out.|
|Appears in Collections:||Article|
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