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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/8739

Title: Thiol peroxidase-like activity of some intramolecularly coordinated diorganyl diselenides
Authors: KUMAR, S
SINGH, HB
Keywords: synthetic organoselenium compounds
glutathione-peroxidase
antioxidant activity
crystal-structure
derivatives
selenium
ebselen
intermediate
reactivity
compound
Issue Date: 2005
Publisher: INDIAN ACADEMY SCIENCES
Citation: JOURNAL OF CHEMICAL SCIENCES, 117(6), 621-628
Abstract: Several new diaryl diselenides having intramolecular coordinating groups have been synthesized by ortho-lithiation/Na2Se2 routes in good yield. Bis[2-(N-phenylferrocenecarboxamide)] diselenide (10), bis[2-(N-tert-butylferrocenecarboxamide)] diselenide (11), (S)(S)-bis[2(-N-phenethylferocene-carboxamide)] diselenide (12) were synthesized by the ortho-lithiation route. Bis[2-(N,N-dimethylaminomethyinaphthyl)] diselenide (13) was synthesized by lithium/bromide exchange reaction whereas bis(2,4-dinitrophenyl) diselenide (14) was prepared by the reaction of disodium diselenide with 2,4dinitro-1-chlorobenzene. Thiol peroxidase-like activities of the diorganodiselenides have been evaluated by using H2O2 as substrate and PhSH as cosubstrate. Diselerrides (13) and (14) with dimethylaminomethyl- or nitro-donor groups in close proximity to selenium, show much better thiol peroxidase-like activities compared to diselenides 10-12 with amide donor groups. Cyclic voltammetry study of diselenides 10-12 derived from redox-active ferrocenamide has been carried out.
URI: http://dx.doi.org/10.1007/BF02708290
http://dspace.library.iitb.ac.in/xmlui/handle/10054/8739
http://hdl.handle.net/10054/8739
ISSN: 0253-4134
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