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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/8558

Title: Epigenetics of the yeast galactose genetic switch
Authors: BHAT, PJ
IYER, RS
Keywords: saccharomyces-cerevisiae
escherichia-coli
gal
memory
heterogeneity
induction
evolution
regulon
network
Issue Date: 2009
Publisher: INDIAN ACAD SCIENCES
Citation: JOURNAL OF BIOSCIENCES, 34(4), 513-522
Abstract: The transcriptional activation of enzymes involved in galactose utilization (GAL genes) in Saccharomyces cerevisiae is regulated by a complex interplay between three regulatory proteins encoded by GAL4 (transcriptional activator), GAL3 (signal transducer) and GAL80 (repressor). The relative concentrations of the signal transducer and the repressor are maintained by autoregulation. Cells disabled for autoregulation exhibit phenotypes distinctly different from that of the wild type cells, enabling us to explore the biological significance of autoregulation. The redundancy in signal transduction due to the presence of GAL1 (alternate signal transducer) also makes it a suitable model to understand the phenomenon of epigenetics. In this article we review some of the recent attempts made to understand the importance of epigenetics in the establishment of cellular and transcriptional memory.
URI: http://dspace.library.iitb.ac.in/xmlui/handle/10054/8558
http://hdl.handle.net/10054/8558
ISSN: 0250-5991
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