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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/832

Title: Transition metal saccharide chemistry and biology: syntheses, characterization, solution stability and putative bio-relevant studies of iron–saccharide complexes
Authors: RAO, CHEBROLU P
GEETHA, K
RAGHAVAN, MSS
SREEDHARA, A
TOKUNAGA, K
YAMAGUCHI, T
JADHAV, V
GANESH, KN
KRISHNAMOORTHY, THANUJA
RAMAIAH, KOLLURU VA
BHATTACHARYYA, RK
Keywords: transition metal saccharide
solution stability
putative bio-relevant studies
electrochemical studies
magnetic studies
exafs spectra
Issue Date: 2000
Publisher: Elsevier
Citation: Inorganica Chimica Acta 297(1-2), 373-382
Abstract: A number of Fe(III) complexes of saccharides and their derivatives, and those of ascorbic acid were synthesized, and characterized by a variety of analytical, spectral (FT-IR, UV–Vis, EPR, Mössbauer and EXAFS), magnetic and electrochemical techniques. Results obtained from various methods have shown good correlations. Data obtained from EPR, magnetic susceptibility and EXAFS techniques could be fitted well with the mono-, di- and trinuclear nature of the complexes. The solution stability of these complexes has been established using UV–Vis absorption and cyclic voltammetric techniques as a function of pH of the solution. Mixed valent, Fe(II,III) ascorbate complexes have also been synthesized and characterized. Reductive release of Fe(II) from the complexes using sodium dithionite has been addressed. In vitro absorption of Fe(III)–glucose complex has been studied using everted sacs of rat intestines and the results have been compared with that of simple ferric chloride. Fe(III)–saccharide complexes have shown regular protein synthesis even in hemin-deficient rabbit reticulocyte lysate indicating that these complexes play a role that is equivalent to that played by hemin in order to restore the normal synthesis of protein. These complexes have exhibited enhanced DNA cleavage properties in the presence of hydrogen peroxide with pUC-18 DNA plasmid.
URI: http://dx.doi.org/10.1016/S0020-1693(99)00364-3
http://hdl.handle.net/10054/832
http://dspace.library.iitb.ac.in/xmlui/handle/10054/832
ISSN: 0020-1693
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