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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/8027

Title: Silica-Coated Liposomes for Insulin Delivery
Authors: DWIVEDI, N
ARUNAGIRINATHAN, MA
SHARMA, S
BELLARE, J
Keywords: controlled drug-delivery
poorly soluble drugs
controlled-release
microporous silica
raman-spectroscopy
oral delivery
nanoparticles
vesicles
systems
spheres
Issue Date: 2010
Publisher: HINDAWI PUBLISHING CORPORATION
Citation: JOURNAL OF NANOMATERIALS, (), -
Abstract: Liposomes coated with silica were explored as protein delivery vehicles for their enhanced stability and improved encapsulation efficiency. Insulin was encapsulated within the fluidic phosphatidylcholine lipid vesicles by thin film hydration at pH 2.5, and layer of silica was formed above lipid bilayer by acid catalysis. The presence of silica coating and encapsulated insulin was identified using confocal and electron microscopy. The native state of insulin present in the formulation was evident from Confocal Micro-Raman spectroscopy. Silica coat enhances the stability of insulin-loaded delivery vehicles. In vivo study shows that these silica coated formulations were biologically active in reducing glucose levels.
URI: http://dx.doi.org/10.1155/2010/652048
http://dspace.library.iitb.ac.in/xmlui/handle/10054/8027
http://hdl.handle.net/10054/8027
ISSN: 1687-4110
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