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Title: Inhibition of succinic semialdehyde dehydrogenase by N-formylglycine
Authors: KUMAR, S
Issue Date: 1998
Citation: JOURNAL OF ENZYME INHIBITION, 13(5), 369-376
Abstract: N-formylglycine was developed as a dead-end inhibitor of the succinic semialdehyde dehydrogenase reaction. At 4mM, it inhibited Aspergillus niger succinic semialdehyde dehydrogenase by 40%. N-formylglycine is a reversible, complete inhibitor; the inhibition is competitive with succinic semialdehyde and uncompetitive with respect to NAD(+) and the K-i values are 4.9 and 10.4 mM respectively. Potato succinic semialdehyde dehydrogenase is also inhibited by N-formylglycine to a similar extent, the nature of the inhibition being identical to that observed with the A. niger enzyme.
ISSN: 8755-5093
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