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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/760

Title: First and unexpected synthesis of macrocyclic cyclophane-based unusual α-amino acid derivatives by phosphazene base without high dilution conditions
Authors: KOTHA, SAMBASIVARAO
HALDER, SOMNATH
DAMODHARAN, LAKSHMINARASIMHAN
PATTABHI, VASANTHA
Keywords: macrocylic cyclophane
phase-transfer catalysis
ptc
Issue Date: 2002
Publisher: Elsevier
Citation: Bioorganic & Medicinal Chemistry Letters 12(7), 1113-1115
Abstract: First synthesis of a macrocylic cyclophane-based unusual α-amino acid derivative 11 by coupling of ethyl isocyanoacetate with 1,2-bis(4-bromomethylphenyl)ethane under phase-transfer catalysis (PTC) conditions. Phosphazene base such as 2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine (BEMP) is useful to improve the yield of cyclophane derivative without high dilution conditions.
URI: http://dx.doi.org/10.1016/S0960-894X(02)00068-9
http://hdl.handle.net/10054/760
http://dspace.library.iitb.ac.in/xmlui/handle/10054/760
ISSN: 0960-894X
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