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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/7235

Title: Transition metal saccharide chemistry and biology: Vanadyl-monosaccharide complexes and their in vitro effect on pUC-18 DNA
Authors: BANDWAR, RP
RAO, CP
Keywords: oxovanadium(iv) complexes
hydrogen-peroxide
d-fructose
d-glucose
electrochemistry
cleavage
spectroscopy
derivatives
reduction
mechanism
Issue Date: 1997
Publisher: ELSEVIER SCIENCE INC
Citation: JOURNAL OF INORGANIC BIOCHEMISTRY, 68(1), 1-6
Abstract: Solid state complexes of VO2+ were synthesized from methanolic solutions of VOCl2 and sodium salt of the hexoses (D = Glc, D-Fra, D-Gal) and pentoses (D-Xyl, D-Rib). The complexes were characterized by diffuse reflectance, aqueous solution absorbance, CD, FTIR, EPR spectroscopies, CV, and elemental analysis. The complexes were found to be mononuclear with a general formula, Na-2[VO(Sacch)(2)(OH)Cl] and these are different those reported earlier which were synthesised by a different route. The aqueous solution stability and pH variation studies of these complexes have shown formation of polymeric species as monitored by UV-visible absorption spectroscopy and cyclic voltammetry. All the complexes exhibited enhanced structural alterations of pUC-18 DNA in the presence of hydrogen peroxide, based on in vitro studies. (C) 1997 Elsevier Science Inc.
URI: http://dx.doi.org/10.1016/S0162-0134(97)81615-7
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7235
http://hdl.handle.net/10054/7235
ISSN: 0162-0134
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