DSpace
 

DSpace at IIT Bombay >
IITB Publications >
Article >

Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/7227

Title: SYNTHESIS, CHARACTERIZATION, DNA-BINDING, AND CYTOTOXIC STUDIES OF SOME MIXED-LIGAND PALLADIUM(II) AND PLATINUM(II) COMPLEXES OF ALPHA-DIIMINE AND AMINO-ACIDS
Authors: MITAL, R
SRIVASTAVA, TS
PAREKH, HK
CHITNIS, MP
Keywords: cyto-toxicity
anti-cancer
2,2'-bipyridine
agents
drugs
Issue Date: 1991
Publisher: ELSEVIER SCIENCE INC
Citation: JOURNAL OF INORGANIC BIOCHEMISTRY, 41(2), 93-103
Abstract: The syntheses of nine palladium(II) complexes of type [Pd(phen)(AA)]+ (where AA is an anion of glycine, L-alanine, L-leucine, L-phenylalanine, L-tyrosine, L-tryptophan, L-valine, L-proline, or L-serine) have been achieved. These palladium(II) complexes have been characterized by ultraviolet-visible, infrared, and H-1 NMR spectroscopy. The binding studies of several complexes [M(NN)(AA)]+ (where M is Pd(II) as Pt(II), NN is 2,2'-bipyridine or 1,10-phenanthrodine, and AA is an anion of amino acid) with calf thymus DNA have been carried out using UV difference absorption and fluorescence spectroscopy. The mode of binding of the above complexes to DNA suggests the involvement of the hydrogen bonding between them. Several complexes [M(phen)(AA)]+ (where M is Pd(II) or Pt(II) and AA is an anion of amino acid) have also been screened for cytotoxicity in P388 lymphocytic cells. Of them, only two complexes, [Pd(Phen)(Gly)]+ and [Pd(phen)(Val)]+, show comparable cytotoxicity, as cisplatin does.
URI: http://dx.doi.org/10.1016/0162-0134(91)80003-Z
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7227
http://hdl.handle.net/10054/7227
ISSN: 0162-0134
Appears in Collections:Article

Files in This Item:

There are no files associated with this item.

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback