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|Title:||SOME POTENTIAL ANTITUMOR 2,2'-DIPYRIDYLAMINE PT(II)/PD(II) COMPLEXES WITH AMINO-ACIDS - THEIR SYNTHESIS, SPECTROSCOPY, DNA-BINDING, AND CYTOTOXIC STUDIES|
|Keywords:||Ligand Platinum(Ii) Complexes|
|Publisher:||ELSEVIER SCIENCE INC|
|Citation:||JOURNAL OF INORGANIC BIOCHEMISTRY, 50(1), 9-20|
|Abstract:||Four new palladium(II) and platinum(II) complexes of formula [M(dipy)(AA)]+ (where dipy is 2,2'-dipyridylamine, AA is an anion of glycine or L-alanine, and M is Pd(II) or Pt(II)) have been synthesized and characterized with amino acids binding as bidentate ligands. These complexes are 1:1 electrolyte in conductivity water. Of the above four complexes, the two L-alanine complexes show ID50 values against P388 lymphocytic leukemia cells lower than cis-diamminedichloroplatinum(II), whereas the two glycine complexes show ID50 values higher than cisplatin. The interaction of calf thymus DNA with the above complexes shows significant spectral changes in the presence of [Pt(dipy)(gly)]Cl, [Pd(dipy)(ala)]Cl, and [Pt(dipy)(ala)]Cl and the mode of binding between these complexes and DNA seems to be noncovalent.|
|Appears in Collections:||Article|
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