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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/7215

Title: SOME POTENTIAL ANTITUMOR 2,2'-DIPYRIDYLAMINE PT(II)/PD(II) COMPLEXES WITH AMINO-ACIDS - THEIR SYNTHESIS, SPECTROSCOPY, DNA-BINDING, AND CYTOTOXIC STUDIES
Authors: PAUL, AK
MANSURITORSHIZI, H
SRIVASTAVA, TS
CHAVAN, SJ
CHITNIS, MP
Keywords: ligand platinum(ii) complexes
palladium(ii) complexes
2,2'-bipyridine
diimine
agents
Issue Date: 1993
Publisher: ELSEVIER SCIENCE INC
Citation: JOURNAL OF INORGANIC BIOCHEMISTRY, 50(1), 9-20
Abstract: Four new palladium(II) and platinum(II) complexes of formula [M(dipy)(AA)]+ (where dipy is 2,2'-dipyridylamine, AA is an anion of glycine or L-alanine, and M is Pd(II) or Pt(II)) have been synthesized and characterized with amino acids binding as bidentate ligands. These complexes are 1:1 electrolyte in conductivity water. Of the above four complexes, the two L-alanine complexes show ID50 values against P388 lymphocytic leukemia cells lower than cis-diamminedichloroplatinum(II), whereas the two glycine complexes show ID50 values higher than cisplatin. The interaction of calf thymus DNA with the above complexes shows significant spectral changes in the presence of [Pt(dipy)(gly)]Cl, [Pd(dipy)(ala)]Cl, and [Pt(dipy)(ala)]Cl and the mode of binding between these complexes and DNA seems to be noncovalent.
URI: http://dx.doi.org/10.1016/0162-0134(93)80010-7
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7215
http://hdl.handle.net/10054/7215
ISSN: 0162-0134
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