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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/7162

Title: CYTOTOXICITY AND DNA-BINDING STUDIES OF SEVERAL PLATINUM-(II) AND PALLADIUM-(II) COMPLEXES OF THE 2,2'-BIPYRIDINE AND AN ANION OF 2-PYRIDINECARBOXYLIC 2-PYRAZINECARBOXYLIC ACID
Authors: MANSURITORSHIZI, H
SRIVASTAVA, TS
CHAVAN, SJ
CHITNIS, MP
Keywords: mixed-ligand palladium(ii)
amino-acids
platinum(ii) complexes
agents
Issue Date: 1992
Publisher: ELSEVIER SCIENCE INC
Citation: JOURNAL OF INORGANIC BIOCHEMISTRY, 48(1), 63-70
Abstract: Four water soluble complexes of the type [M(bpy)(a-X)]NO3, where M is Pd(II) or Pt(II), bpy is 2,2-bipyridine, and a-x is anion of 2-pyridinecarboxylic acid or 2-pyrazinecarboxylic acid, have been found to bind calf thymus DNA, possibly through hydrogen binding. [M(bpy)(2-py)]NO3 complexes (2-py is an anion of 2-pyridinecarboxylic acid) show I.D.50 values smaller than cisplatin whereas [M(bpy)(2-pyz)]NO3 complexes (2-pyz is an anion of 2-pyrazinecarboxylic acid) show I.D.50 values larger than cisplatin against P388 cancer cells.
URI: http://dx.doi.org/10.1016/0162-0134(92)80054-Y
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7162
http://hdl.handle.net/10054/7162
ISSN: 0162-0134
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