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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/7111

Title: Transition metal saccharide chemistry and biology: Synthesis, characterization, electrochemistry and EPR studies of oxovanadium(IV) complexes of saccharides and their derivatives and in vitro interaction of some of these with ribonuclease and deoxyribonuclease
Authors: SREEDHARA, A
RAO, CP
RAO, BJ
Keywords: titanium-carbohydrate complexes
electron-spin-resonance
enantioselective syntheses
aqueous-solution
iron(iii) complexes
state-analog
blood-cells
vanadate
coordination
spectroscopy
Issue Date: 1996
Publisher: ELSEVIER SCIENCE BV
Citation: CARBOHYDRATE RESEARCH, 289(), 39-53
Abstract: Low molecular weight, water-soluble saccharide complexes of oxovanadium(IV) have been synthesized and characterized by analytical, spectroscopic and electrochemical techniques. All the complexes were found to be mononuclear, possessing the VO2+ moiety, These are shown to be hydrolytically and oxidatively stable over a wide range of pH (1-12) and have been extensively characterized by absorption and EPR spectroscopy and by electrochemistry, Several correlations have been drawn from the data generated. Some of these complexes have been demonstrated to possess in vitro RNase inhibition activity with no effect on DNase. This suggests that these molecules closely mimic the substrate portion of the RNase-catalysed RNA hydrolysis and can act as transition-state analogues to RNase. (C) 1996 .
URI: http://dx.doi.org/10.1016/0008-6215(96)00100-0
http://dspace.library.iitb.ac.in/xmlui/handle/10054/7111
http://hdl.handle.net/10054/7111
ISSN: 0008-6215
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