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Title: Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity
Authors: SINGH, ANIL K
Keywords: Liposome
Retinol Palmitate
Issue Date: 1998
Publisher: Elsevier
Citation: Biophysical Chemistry 73(1-2), 155-162
Abstract: Absorption and fluorescence studies of retinol (vitamin A alcohol) and retinol palmitate (vitamin A palmitate) intercalated in phosphatidylcholine (PC) liposomes show that these compounds are bound to the lipid bilayer. It is further found that retinol binds liposomes with greater affinity as compared to retinol palmitate. In addition, the delivery of liposome-incorporated retinoids to the blood has also been studied and it is found that these systems reduce blood viscosity and cause less lysis of red blood cells than retinoid compounds not complexed in liposomes.
ISSN: 0301-4622
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