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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/6867

Title: pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery
Authors: RISBUD, MV
HARDIKAR, AA
BHAT, SV
BHONDE, RR
Keywords: oral sustained delivery
drug-delivery
helicobacter-pylori
invitro
ulcer
Issue Date: 2000
Publisher: ELSEVIER SCIENCE BV
Citation: JOURNAL OF CONTROLLED RELEASE, 68(1), 23-30
Abstract: The aim of this study was to develop a pH-sensitive chitosan/polyvinyl pyrrolidone (PVP) based controlled drug release system for antibiotic delivery. The hydrogels were synthesised by crosslinking chitosan and PVP blend with glutaraldehyde to form a semi-interpenetrating polymer network (semi-IPN). The semi-IPN formation was confirmed by Fourier transform infrared spectroscopic (FTIR) analysis. Semi-IPNs, viz, air-dried and freeze-dried, were compared for their surface morphology, wettability, swelling properties and pH-dependent swelling. Air- and freeze-dried membranes were also incorporated with amoxicillin and antibiotic release was studied. Porous freeze-dried hydrogels (pore diameter, 39.20+/-2.66 mu m) exhibited superior pH-dependent swelling properties over non-porous air-dried hydrogels. A high octane contact angle (144.20+/-0.580) of hydrogel was indicative of its hydrophilic nature. Increased swelling of hydrogels, under acidic conditions, was due to the protonation of a primary amino group on chitosan, as confirmed by FTIR analysis. Freeze-dried membranes released around 73% of the amoxicillin (33% by air-dried) in 3 h at pH 1.0 and, thus, had superior drug-release properties to air-dried hydrogels. Freeze-dried membranes could serve as potent candidates for antibiotic delivery in an acidic environment. (C) 2000 .
URI: http://dx.doi.org/10.1016/S0168-3659(00)00208-X
http://dspace.library.iitb.ac.in/xmlui/handle/10054/6867
http://hdl.handle.net/10054/6867
ISSN: 0168-3659
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