DSpace at IIT Bombay >
IITB Publications >
Please use this identifier to cite or link to this item:
|Title: ||Nano-in-micro alginate based hybrid particles|
|Authors: ||JOSHI, A|
|Keywords: ||2-step desolvation method|
|Issue Date: ||2010|
|Publisher: ||ELSEVIER SCI LTD|
|Citation: ||CARBOHYDRATE POLYMERS, 81(4), 790-798|
|Abstract: ||Novel template containing 'Nanoparticles (gelatin and CaCO(3)) embedded in Microspheres' ('Nano-in-micro') was developed using atomization. Dexamethasone loaded gelatin nanoparticles, fluorescein isothiocyanate-dextran (FITC-dex) loaded CaCO(3) nanoparticles and alginate based 'Nano-in-micro' system were prepared and characterized using optical microscopy, SEM, TEM. DLS, zeta potential, CLSM and FTIR. The results indicate that spherical, non-aggregating, 'nano-in-micro' particles (5-60 mu m) can be prepared using atomization technique. Dexamethasone release from gelatin nanoparticles and 'nano-in-micro' systems indicated a decrease in burst release in the order: uncoated (24%) > coated (18%) > 'nano-in-micro' system (1:4 ratio) (17%). The sustained release decreased in order of 'nano-in-micro' (1:4 ratio) (14 days) > coated nanoparticles (9 days)> uncoated nanoparticles (4 days) for 95% drug release. FITC-dex loading and release from CaCO(3) nanoparticles were found to be molecular weight dependent. Thus, 'nano-in-micro' systems show possibility for use as drug release vehicles, biosensors and multifunctional systems.|
|Appears in Collections:||Article|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.