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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/5941

Title: Overexpression of G1/S cyclins and PCNA and their relationship to tyrosine phosphorylation and dephosphorylation during tumor promotion by metanil yellow and malachite green
Authors: SUNDARRAJAN, M
FERNANDIS, AZ
SUBRAHMANYAM, G
PRABHUDESAI, S
KRISHNAMURTHY, SC
RAO, KVK
Keywords: hepatic preneoplastic lesions
epidermal growth-factor
protein phosphatase-activity
rat hepatocyte cultures
n-nitrosodiethylamine
dna-synthesis
breast-cancer
kinase-activity
cell
liver
Issue Date: 2000
Publisher: ELSEVIER SCI IRELAND LTD
Citation: TOXICOLOGY LETTERS, 116(1-2), 119-130
Abstract: Metanil yellow (MY) and Malachite green (MG) are textile dyes, which, despite the ban, occur unscrupulously as food colouring agents. Accordingly they constitute a serious public health hazard and are of sufficient environmental concern. We have earlier reported that both MY and MG have tumor promoting effects on the development of hepatic preneoplastic lesions induced by N-nitrosodielhylamine in rats. In order to understand the possible mechanism(s) by which metanil yellow (MY) and malachite green (MG) promotes liver tumor development, we have studied the tyrosine phosphorylation and protein phosphatases during tumor promotion. We have also investigated the possible overexpression of G1/S cyclins and PCNA during tumor promotion by MY and MG. The present investigation indicates that enhanced tyrosine phosphorylation is associated with no change in levers of tyrosine protein phosphatases. We have also observed an increase in the expression of PCNA and G1/S cyclins during tumor promotion. These factors collectively may contribute to the abnormal cell proliferation during tumor promotion by MY and MG. (C) 2000 Elsevier Science Ireland Ltd. .
URI: http://dx.doi.org/10.1016/S0378-4274(00)00216-2
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5941
http://hdl.handle.net/10054/5941
ISSN: 0378-4274
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