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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/5206

Title: NEW STEROID HAPTENS FOR RADIOIMMUNOASSAY - SYNTHESIS OF STEROIDS SUBSTITUTED WITH THIOETHER OR ESTER LINKAGES AT THE 2-ALPHA-POSITION
Authors: DESAI, UR
TRIVEDI, GK
Issue Date: 1991
Publisher: BUTTERWORTH-HEINEMANN
Citation: STEROIDS, 56(4), 185-188
Abstract: Haptens with bridge at the 2-position have not yet been explored. Radioimmunoassays with antibodies directed against 2-alpha-alkyl bridged steroid haptens are expected to be highly specific due to greater topographical exposure and similarity in conformation to the native steroid. The 2-alpha-alkyl bridged haptens were synthesized by first adding a cyclopropane ring to 2-methylene-4-en-3-one. Selective opening of the three-membered ring with trimethyl silyl iodide and transformation of the iodo group gave a carbocyclic acid, the desired analog for conjugation with protein.
URI: http://dx.doi.org/10.1016/0039-128X(91)90080-F
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5206
http://hdl.handle.net/10054/5206
ISSN: 0039-128X
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