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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/5189

Title: Bioprosthetic heart valves - Replacing order with chaos: Electron microscopic study
Authors: DATTA, D
KUNDU, PK
BANDYOPADHYAY, BN
Keywords: edwards porcine bioprosthesis
follow-up
starr-edwards
experience
5-year
replacements
prosthesis
xenograft
position
failure
Issue Date: 1999
Publisher: BLACKWELL SCIENCE INC
Citation: ARTIFICIAL ORGANS, 23(4), 372-376
Abstract: Rheumatic heart disease is a significant clinical entity in young children; especially in the developing world. One of the major long-term effects of iii managed rheumatic fever is irreversible damage to the cardiac valve leaflets, primarily on the left side. With the limited success of currently available mechanical and bioprosthetic valves, there is an urgent need for new directions in bioprosthetic valves, both in material, including source, degree of fixation, surface, bulk modifications, etc., and design. In the present paper, new proposals in the material selection and fabrication of bioprosthetic valves are proposed based on electron microscopic studies of natural valve leaflets and the pericardial surface. Current approaches for bioprosthetic valve fabrications include the wide use of the pericardium as a leaflet material. The present study indicates a need for nondestructive surface examination of pericardial sheets for the elimination of areas of surface voids resulting from gross fiber disorientation. Also, there seems to be a need for incorporation of an insitu fiber renewal mechanism in bioprosthetic leaflets to emulate the natural valve more closely. Apparently natural leaflets have built-in fiber renewal mechanism(s).
URI: http://dx.doi.org/10.1046/j.1525-1594.1999.06191.x
http://dspace.library.iitb.ac.in/xmlui/handle/10054/5189
http://hdl.handle.net/10054/5189
ISSN: 0160-564X
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