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Title: Data mining of VDJ genes reveals interesting clues
Authors: JOSHI, RR
Issue Date: 2006
Citation: PROTEIN AND PEPTIDE LETTERS, 13(6), 587-593
Abstract: Hypervariability of the complementary determining regions in characteristic structure of Immnoglobulins and the distinct, cell-specific expressions of the genes coding for this important class of proteins pose intriguing problems in experimental and computational/informatics research requiring a special approach different from those for the other proteins. We present here an Average Linkage Hierarchical Clustering of the Homosapien VIA genes and the Immunoglobulin polypeptides generated by them using special kind of data structures and correlation matrices in place of the microarray data. The results reveal interesting clues on the heterogeneity of exon-intron locations in these gene-families and its possible role in hypervariability of the Immunoglobulins.
ISSN: 0929-8665
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