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|Title:||From sliding nucleosomes to twirling DNA motors|
|Publisher:||AMER SCIENTIFIC PUBLISHERS|
|Citation:||JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE, 3(6), 912-921|
|Abstract:||The sliding of DNA-wrapped protein cylinders, so-called nucleosomes, along DNA is a mechanism presumably involved in exposing wrapped eucaryotic DNA to the molecular machinery. On the other hand, a self-propelling DNA minicircle is an example of a nanotechnological device that can be driven by temperature oscillations employing the ratchet effect. We show parallels between the two systems by demonstrating that a nucleosome in principle could also be turned into such an externally driven nanodevice; in this case the nucleosome would slide in directed fashion along DNA. We demonstrate, however, that the high friction between the DNA and the protein cylinder renders this idea unfeasible.|
|Appears in Collections:||Article|
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