Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/xmlui/handle/10054/4597
Title: From sliding nucleosomes to twirling DNA motors
Authors: KULIC, IM
THAOKAR, R
SCHIESSEL, H
Keywords: Positioned Nucleosomes
Histone Octamer
Brownian Motors
Target Sites
Sequences
Chromatin
Equilibrium
Ligands
Binding
Single
Issue Date: 2006
Publisher: AMER SCIENTIFIC PUBLISHERS
Citation: JOURNAL OF COMPUTATIONAL AND THEORETICAL NANOSCIENCE, 3(6), 912-921
Abstract: The sliding of DNA-wrapped protein cylinders, so-called nucleosomes, along DNA is a mechanism presumably involved in exposing wrapped eucaryotic DNA to the molecular machinery. On the other hand, a self-propelling DNA minicircle is an example of a nanotechnological device that can be driven by temperature oscillations employing the ratchet effect. We show parallels between the two systems by demonstrating that a nucleosome in principle could also be turned into such an externally driven nanodevice; in this case the nucleosome would slide in directed fashion along DNA. We demonstrate, however, that the high friction between the DNA and the protein cylinder renders this idea unfeasible.
URI: http://dx.doi.org/10.1166/jctn.2006.007
http://dspace.library.iitb.ac.in/xmlui/handle/10054/4597
http://hdl.handle.net/10054/4597
ISSN: 1546-1955
Appears in Collections:Article

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