Total Synthesis of (+)-Demethoxycardinalin 3

Abstract

The total synthesis of (+)-demethoxycardmalm 3 is described The synthetic strategy features the synthesis of dimerie Fischer carbene and us use in a biduectional Doi/ benzamulation reaction to set the dimerie structure of the cardmalms. The oxa-picict-Spengler reaction was used to construct the pyran rings The synthesis as completed in seven steps and an overall yield of 7%