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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/4068

Title: Some Mechanistic Insights into the Gelation of Regenerated Silk Fibroin Sol
Authors: NAGARKAR, S
PATIL, A
LELE, A
BHAT, S
BELLARE, J
MASHELKAR, RA
Keywords: bombyx-mori
in-vitro
rheological behavior
hydrogels
gene
biomaterials
scaffolds
rheometry
proteins
gland
Issue Date: 2009
Publisher: AMER CHEMICAL SOC
Citation: INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 48(17), 8014-8023
Abstract: We provide some new insights into the kinetics and mechanism of sol-gel transition as it pertains to regenerated silk fibroin, which is the principle structural protein of silkworm silk fiber. Silk fibroin was dissolved in lithium bromide and dialyzed against deionized water to prepare a regenerated fibroin solution. This solution was found to be unstable at lower pH and transformed into a colloidal gel. The kinetics and mechanism of the sol-gel transition were investigated using rheology and light scattering. We show that gelation proceeds in two steps. In the first step, a weak gel is formed almost immediately upon lowering the pH, while in the second step further gelation proceeds rapidly after a long induction time to form a self-similar structure.
URI: http://dx.doi.org/10.1021/ie801723f
http://dspace.library.iitb.ac.in/xmlui/handle/10054/4068
http://hdl.handle.net/10054/4068
ISSN: 0888-5885
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