DSpace
 

DSpace at IIT Bombay >
IITB Publications >
Article >

Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/3917

Title: Intramolecularly coordinated diorganyl ditellurides: Thiol peroxidase-like antioxidants
Authors: MUGESH, G
PANDA, A
KUMAR, S
APTE, SD
SINGH, HB
BUTCHER, RJ
Keywords: chalcogenopyrylium trimethine dyes
active organoselenium compound
macrocyclic schiff-base
x-ray structure
glutathione-peroxidase
photodynamic therapy
chalcogenapyrylium dyes
lipid-peroxidation
singlet-oxygen
photochemotherapeutic agents
Issue Date: 2002
Publisher: AMER CHEMICAL SOC
Citation: ORGANOMETALLICS, 21(5), 884-892
Abstract: A series of diaryl ditellurides with and without coordinating amino/imino groups are synthesized by using either the Grignard route or the heteroatom-directed aromatic lithiation route. The chiral ditelluride (R),(R)-bis[2-(4-ethyl-2-oxazolinyl)phenyl] ditelluride is synthesized in an enantiomerically pure form by stereoselective ortho-lithiation. The thiol peroxidase activity of the ditellurides is studied by using H2O2 as a substrate and PhSH as a cosubstrate. The initial rates for the reduction of H2O2 catalyzed by diaryl ditellurides are much higher than those catalyzed by the corresponding diselenides. A comparison of the activities between various diorganyl ditellurides and diselenides shows that the presence of basic amino groups in the close proximity of tellurium enhances the reduction rates and the effect of amino groups on the activity is more pronounced in the case of ditellurides as compared to the corresponding diselenides. On the other hand, a correlation between the strength of Te...N intramolecular interactions and thiol peroxidase activity reveals that the strong Te...N interactions reduce the thiol peroxidase activity of amino/imino-substituted ditellurides. A plot of Te...N distances against Te-125 NMR chemical shifts shows a linear correlation.
URI: http://dx.doi.org/10.1021/om010759z
http://dspace.library.iitb.ac.in/xmlui/handle/10054/3917
http://hdl.handle.net/10054/3917
ISSN: 0276-7333
Appears in Collections:Article

Files in This Item:

There are no files associated with this item.

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback