DSpace
 

DSpace at IIT Bombay >
IITB Publications >
Article >

Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/3854

Title: Ferrite-Silica-Insulin Nanocomposites (FeSINC) for Glucose Reduction
Authors: DWIVEDI, N
ARUNAGIRINATHAN
SHARMA, S
BELLARE, J
Keywords: controlled drug-delivery
raman-spectroscopy
nanoparticles
systems
carrier
spheres
Issue Date: 2010
Publisher: AMER CHEMICAL SOC
Citation: LANGMUIR, 26(1), 357-361
Abstract: Proteins find a more stable environment upon encapsulation in a silica host, because of the polymeric silica frame that grows around the macromolecule and protects them from denaturation. Silica-insulin nanocomposite (SINC) and ferrite-coated SINC (FeSINC) was prepared by polyelectrolytic condensation of silica precursor on insulin and they were studied for their ability to control glucose levels. SINC was prepared by acid-base-catalyzed polymerization in the presence Of insulin at room temperature by a modified Stober's process. FeSINC nanoparticles were prepared by coprecipitation of both ferric and ferrous salts on the bovine bovine insulin loaded silica nanoparticle. The presence of ferrite coating in FeSINC was identified using a vibrating sample magnetometer and quantified from XRF study. The intermolecular interactions in these nanocomposites were studied by FTIR and Raman spectroscopy. All in vivo study indicated that FeSINC was biologically active in reducing glucose levels as compared to SINC.
URI: http://dx.doi.org/10.1021/la902094c
http://dspace.library.iitb.ac.in/xmlui/handle/10054/3854
http://hdl.handle.net/10054/3854
ISSN: 0743-7463
Appears in Collections:Article

Files in This Item:

There are no files associated with this item.

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback