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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/3466

Title: One electron reduction of vanadate(V) to oxovanadium(IV) by low-molecular-weight biocomponents like saccharides and ascorbic acid: Effect of oxovanadium(IV) complexes on pUC18 DNA and on lipid peroxidation in isolated rat hepatocytes
Authors: SREEDHARA, A
SUSA, N
PATWARDHAN, A
RAO, CP
Issue Date: 1996
Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Citation: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 224(1), 115-120
Abstract: One electron reduction of vanadate(V) to vanadyl(IV) occurs in the presence of biocomponents, such as, saccharides and L-ascorbic acid under physiological conditions. The vanadyl(IV) complexes thus generated have been demonstrated to introduce nicks in pUC18 DNA in the absence or in the presence of hydrogen peroxide and also exhibit lipid peroxidation in isolated rat hepatocytes. Thus the reducing and complexing abilities of these molecules may help in understanding the in vivo reduction and the resultant toxicity to cells incubated with vanadate(V). (C) 1996 .
URI: http://dx.doi.org/10.1006/bbrc.1996.0993
http://dspace.library.iitb.ac.in/xmlui/handle/10054/3466
http://hdl.handle.net/10054/3466
ISSN: 0006-291X
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