Water-soluble Tc-99m-labeled dendritic novel porphyrins tumor imaging and diagnosis

Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/3336

Title:	Water-soluble Tc-99m-labeled dendritic novel porphyrins tumor imaging and diagnosis
Authors:	SUBBARAYAN, M SHETTY, SJ SRIVASTAVA, TS NORONHA, OPD SAMUEL, AM MUKHTAR, H
Keywords:	starburst polyamidoamine dendrimers photodynamic therapy efficient transfer cascade polymers contrast agents tissue cells
Issue Date:	2001
Publisher:	ACADEMIC PRESS INC
Citation:	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 281(1), 32-36
Abstract:	We have synthesized two water soluble dendritic porphyrins, termed DP1 and DP2 and have successfully radiolabeIed them with Tc-99m. These Tc-99m-labeled porphyrins were administered to C-6-glioma tumor bearing Wistar rats and scintiimaging and biodistribution studies were carried out. Tumor to muscle ratios of DP1 and DP2 were 8.0 and 9.7, respectively. These molecules may have potential for tumor imaging and diagnosis and may even prove useful as photosensitizers in photodynamic therapy applications.
URI:	http://dx.doi.org/10.1006/bbrc.2001.4289 http://dspace.library.iitb.ac.in/xmlui/handle/10054/3336 http://hdl.handle.net/10054/3336
ISSN:	0006-291X
Appears in Collections:	Article

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