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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/12896

Title: Evaluation studies of technetium-99m-porphyrin (T3,4BCPP) for tumor imaging
Authors: SUBBARAYAN, M
SHETTY, SJ
SRIVASTAVA, TS
NORONHA, OPD
SAMUEL, AM
Keywords: photodynamic therapy
photosensitizers
porphyrin
tissue
model
Issue Date: 2001
Publisher: WORLD SCI PUBL CO INC
Citation: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, 5(12), 824-828
Abstract: A water-soluble porphyrin, 5,10,15,20-tetrakis[3,4-bis(carboxymethyleneoxy)phenyl] porphyrin (T3,4BCPP), was successfully labeled with (99m)Tc and biodistribution studies were performed in Wistar rats. Scintiimaging and in vivo distribution studies were also carried out in C(6)-gliomas and mammary tumor-bearing animals using a gamma camera. Tumor-to-muscle (T/M) ratios were calculated and compared with those obtained with the known tumor-seeking radiopharmaceuticals (99m)Tc(V)-DMSA (DMSA = dimercaptosuccinic acid), (99m)Tc-citrate and (201)TICl. In the case of C(6)-gliomas, the ratios were 4.2, 2.2, 4.00 and 3.0; while in the case of C(3)H/J mammary tumor, the ratios were 9.4, 8.8, 8.1 and 8.5 for T3,4BCPP, (99m)Tc(V)-DMSA, (99m)Tc-citrate and (201)TICl, respectively. Similar studies were carried out in N-methyl-N-nitrosourea (NMU)-induced mammary tumor animals and the T/M ratios obtained were 5.9, 2.0, 5.3 and 3.3 for T3,4BCPP, (99m)Tc(V)-DMSA, (99m)Tc-citrate and (201)TICl, respectively. The radiolabeled photosensitizer could perhaps be used to detect cancer non-invasively and could even prove useful in monitoring the progression/regression of tumors before, during, and after chemotherapy, radiation therapy or photodynamic therapy (PDT). Copyright (C) 2001 John Wiley Sons, Ltd.
URI: http://dx.doi.org/10.1002/jpp.546
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12896
http://hdl.handle.net/10054/12896
ISSN: 1088-4246
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