Please use this identifier to cite or link to this item:
|Title:||Convenient synthesis, characterization and GPx-like catalytic activity of novel ebselen derivatives|
Chiral Selenium Electrophiles
Volatile Cvd Precursors
|Publisher:||WILEY-V C H VERLAG GMBH|
|Citation:||EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (18), 3857-3864|
|Abstract:||The synthesis and characterization of benzisochalcogenazolones (ebselen derivatives 16-21) is described. The synthesis of 16-21 was achieved by treating the bromo precursors 11-13 with an appropriate dilithium dichalcogenide. The synthesis of benzisoselenazolones 16 and 18 was also accomplished by an alternative route, that is, by treating the corresponding methoxymethyl selenides 22 and 23 with 1 equiv. of bromine. The synthesis of methoxymethyl selenides 22 and 23 was accomplished by lithiation of the bromo precursors followed by treatment with bis(methoxymethyl) diselenide. The benzisoselenazolones 16 and 17 were characterized by single-crystal X-ray techniques. The GPx-like catalytic activities of compounds 16-18 and 21 were determined by using the coupled reductase assay. Compound 16 was found to be less active than ebselen 8 whereas compounds 17 and 18 were more active than ebselen in this assay. Compound 21 showed a 1.5-fold higher activity than its selenium analogue 17. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).|
|Appears in Collections:||Article|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.