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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/12808

Title: Constrained phenylalanine derivatives by enyne metathesis and Diels-Alder reaction
Authors: KOTHA, S
SREENIVASACHARY, N
BRAHMACHARY, E
Keywords: amino-acid derivatives
glycine equivalent
organic-synthesis
peptidomimetics
analogs
discovery
receptor
route
phe
Issue Date: 2001
Publisher: WILEY-V C H VERLAG GMBH
Citation: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (4), 787-792
Abstract: A conceptually new approach for the synthesis of indane-based alpha -amino acid derivatives is reported. In this regard, the synthesis of five-membered exocyclic and five-membered inner-outer ring diene building blocks (7 and 15) containing alpha -amino acid moieties is described. Diene 15 is prepared by an enyne metathesis reaction as a key step. In this paper, a full account of our work regarding the Diels-Alder reaction of these dienes with various dienophiles, and the subsequent oxidation of the cycloadducts to give various indane-based alpha -amino acid derivatives is reported.
URI: http://dspace.library.iitb.ac.in/xmlui/handle/10054/12808
http://hdl.handle.net/10054/12808
ISSN: 1434-193X
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