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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/12804

Title: Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover
Authors: SUBRAHMANYAM, G
RUDD, CE
SCHNEIDER, H
Keywords: signal-transduction
phosphoinositide kinases
protein-kinase
cross-linking
4-kinase
3-kinase
lymphocytes
phosphorylation
requirement
expression
Issue Date: 2003
Publisher: WILEY-V C H VERLAG GMBH
Citation: EUROPEAN JOURNAL OF IMMUNOLOGY, 33(1), 46-52
Abstract: CD7 is a 40-kDa glycoprotein that is expressed on prothymocytes and persists during T cell differentiation. CD7 has been demonstrated to generate, like other costimulatory molecules, intracellular signals that modulate T cell function. However, although it binds to phosphatidylinositol 3-kinase (PI 3-kinase), the signaling events mediated by CD7 are not completely understood. In this context, phosphatidylinositol 4-kinase (PI 4-kinase) is a key enzyme involved in a variety of events, from the modeling of the actin cytoskeleton to the activation of protein kinase C. In this study, we show for the first time that PI 4-kinase of 55 kDa can associate with CD7. The enzyme activity was insensitive to wortmannin, but was inhibited by adenosine, a characteristic for type II PI 4-kinase. Together, our findings demonstrate that type II PI 4-kinases are integral components of the CD7 signaling pathway and may play a role of CD7 in co-stimulation and thymic differentiation.
URI: http://dx.doi.org/10.1002/immu.200390006
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12804
http://hdl.handle.net/10054/12804
ISSN: 0014-2980
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