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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/12773

Title: Fluorescence Investigation of the Binding of Model PDT Drugs to Nonionic and Zwitterionic Surfactants
Authors: PATEL, S
DATTA, A
Keywords: chlorin p(6)
cremophor-el
ph
aggregation
purpurin-18
derivatives
albumin
plasma
Issue Date: 2009
Publisher: WILEY-BLACKWELL PUBLISHING, INC
Citation: PHOTOCHEMISTRY AND PHOTOBIOLOGY, 85(3), 725-732
Abstract: The binding of two model photodynamic therapy drugs, chlorin p(6) and purpurin 18, with surfactants has been studied using steady-state and time-resolved fluorescence techniques. The surfactants used are amphiphilic nonionic surfactant (Tween 80 and Tween 40) and zwitterionic surfactant (HAPS). These have applications in drug delivery. The studies have been performed at pH 7 and 5 for chlorin p(6) and at pH 7 for purpurin 18. The binding constants have been estimated from the change in fluorescence parameters and have been compared with those for Cremophor EL and human serum albumin. Chlorin p(6) is found to bind to the surfactants to a greater extent at pH 5 than at pH 7. The same ionic species of chlorin p(6) is found to exist at the maximum concentrations of the surfactants.
URI: http://dx.doi.org/10.1111/j.1751-1097.2008.00486.x
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12773
http://hdl.handle.net/10054/12773
ISSN: 0031-8655
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