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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/12082

Title: Effects of carbenoxolone on syncytial electrical properties and junction potentials of guinea-pig vas deferens
Authors: PALANI, D
GHILDYAL, P
MANCHANDA, R
Keywords: smooth-muscle-cells
synaptic potentials
gap-junctions
current flow
varicosities
communication
transmission
oscillations
contractile
secretion
Issue Date: 2006
Publisher: SPRINGER
Citation: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 374(3), 207-214
Abstract: The effects of the putative gap junction blocker carbenoxolone on smooth muscle syncytial properties and junction potentials were studied in guinea pig vas deferens (GPVD). Treatment with 50 mu M carbenoxolone reversibly and significantly increased input resistance (R-in) ( by 682.5 +/- 326.0 %, P < 0.05) and abolished cable potentials within 6 7 mins of incubation, without disturbing resting membrane potential. Carbenoxolone reversibly and significantly increased the amplitude of spontaneous excitatory junction potentials (sEJPs) by 96.9 +/- 35.45% (P < 0.05), shifted their amplitude distribution rightwards, and reduced their frequency of occurrence by 58.17 +/- 17.7% (P < 0.05), without altering their time courses. Similarly, carbenoxolone increased the amplitude of evoked excitatory junction potentials (eEJPs) by 17.7 +/- 5.88% and tau(decay) by 19.43 +/- 8.29% (P < 0.05). Our results indicate that carbenoxolone alters the electrical properties and junctional potentials of the GPVD by a mechanism consistent with a relatively specific block of gap junctions. These results suggest that gap junction mediated cell-to-cell communication may significantly modulate the electrical properties and junctional potentials of the GPVD and consequently the physiological functioning of this tissue.
URI: http://dx.doi.org/10.1007/s00210-006-0109-7
http://dspace.library.iitb.ac.in/xmlui/handle/10054/12082
http://hdl.handle.net/10054/12082
ISSN: 0028-1298
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