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|Title: ||Effects of carbenoxolone on syncytial electrical properties and junction potentials of guinea-pig vas deferens|
|Authors: ||PALANI, D|
|Issue Date: ||2006|
|Citation: ||NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 374(3), 207-214|
|Abstract: ||The effects of the putative gap junction blocker carbenoxolone on smooth muscle syncytial properties and junction potentials were studied in guinea pig vas deferens (GPVD). Treatment with 50 mu M carbenoxolone reversibly and significantly increased input resistance (R-in) ( by 682.5 +/- 326.0 %, P < 0.05) and abolished cable potentials within 6 7 mins of incubation, without disturbing resting membrane potential. Carbenoxolone reversibly and significantly increased the amplitude of spontaneous excitatory junction potentials (sEJPs) by 96.9 +/- 35.45% (P < 0.05), shifted their amplitude distribution rightwards, and reduced their frequency of occurrence by 58.17 +/- 17.7% (P < 0.05), without altering their time courses. Similarly, carbenoxolone increased the amplitude of evoked excitatory junction potentials (eEJPs) by 17.7 +/- 5.88% and tau(decay) by 19.43 +/- 8.29% (P < 0.05). Our results indicate that carbenoxolone alters the electrical properties and junctional potentials of the GPVD by a mechanism consistent with a relatively specific block of gap junctions. These results suggest that gap junction mediated cell-to-cell communication may significantly modulate the electrical properties and junctional potentials of the GPVD and consequently the physiological functioning of this tissue.|
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