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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/11612

Title: FTSZ INHIBITION: A PROMISING APPROACH FOR ANTI-STAPHYLOCOCCAL THERAPY
Authors: SINGH, P
PANDA, D
Keywords: cell-division protein
resistant staphylococcus-aureus
penicillin-binding proteins
bacillus-subtilis
escherichia-coli
assembly dynamics
peptide inhibitors
surface protein
antibacterial activity
bacterial cytokinesis
Issue Date: 2010
Publisher: PROUS SCIENCE, SA-THOMSON REUTERS
Citation: DRUG NEWS & PERSPECTIVES, 23(5), 295-304
Abstract: Staphylococcus causes a large number of animal and human diseases and has been considered as a major health concern. With the emergence of resistant strains of staphylococcus, like methicillin-resistant Staphylococcus aureus and vancomycin-resistant Staphylococcus aureus, the search for novel antibacterial targets has intensified. FtsZ, a bacterial cytoskeleton protein, is involved in cell division. FtsZ assembles into protofilaments in a GTP-dependent manner, and forms a dynamic Z-ring at the mid-cell position. The assembly dynamics of FtsZ in the Z-ring are regulated by the combined actions of several FtsZ-associated proteins. Furthermore, the interaction of FtsZ with accessory proteins is essential for their recruitment to the Z-ring. A disruption of this interaction perturbs the Z-ring formation. FtsZ inhibitors like PC-190723 have been suggested to inhibit the Staphylococcus cell division by perturbing the assembly and stabitity of FtsZ polymers. In this review, we discuss the assembly dynamics of Z-ring and its role in cell division. In addition, we highlight recent advances suggesting the potential of FtsZ as a drug target for antistaphylococcal therapy.
URI: http://dx.doi.org/10.1358/dnp.2010.23.5.1429489
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11612
http://hdl.handle.net/10054/11612
ISSN: 0214-0934
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