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Please use this identifier to cite or link to this item: http://dspace.library.iitb.ac.in/jspui/handle/10054/11509

Title: Tyrosyl phosphorylation and activation of a type II phosphatidylinositol 4-kinase by p56(lck) in concanavalin A stimulated rat splenic lymphocytes
Authors: FERNANDIS, AZ
SUBRAHMANYAM, G
Keywords: cell antigen-receptor
signal-transduction
protein-kinase
purification
binding
spleen
Issue Date: 2000
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: MOLECULAR IMMUNOLOGY, 37(6), 273-280
Abstract: Recent evidence suggests that concanavalin A modulates tyrosyl phosphorylation and activation of a type II PtdIns 4-kinase in rat splenic lymphocytes. However, the regulatory protein tyrosine kinase(s) remain to be elusive. The present manuscript provides evidence that a type II PtdIns 4-kinase associates with p56(lck) in Con A stimulated rat splenic lymphocytes. In vitro phosphorylation studies suggest that p561(lck) regulates phosphorylation and activation of type II PtdIns 4-kinase. Inhibition of p561(lck) activity in vivo has shown to reduce tyrosyl phosphorylation and activation of PtdIns 4-kinase by Con A. These results suggest that p56(lck) may be the physiological regulator of type II PtdIns 4-kinase. (. .
URI: http://dx.doi.org/10.1016/S0161-5890(00)00053-5
http://dspace.library.iitb.ac.in/xmlui/handle/10054/11509
http://hdl.handle.net/10054/11509
ISSN: 0161-5890
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