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|Title: ||Tyrosyl phosphorylation and activation of a type II phosphatidylinositol 4-kinase by p56(lck) in concanavalin A stimulated rat splenic lymphocytes|
|Authors: ||FERNANDIS, AZ|
|Keywords: ||cell antigen-receptor|
|Issue Date: ||2000|
|Publisher: ||PERGAMON-ELSEVIER SCIENCE LTD|
|Citation: ||MOLECULAR IMMUNOLOGY, 37(6), 273-280|
|Abstract: ||Recent evidence suggests that concanavalin A modulates tyrosyl phosphorylation and activation of a type II PtdIns 4-kinase in rat splenic lymphocytes. However, the regulatory protein tyrosine kinase(s) remain to be elusive. The present manuscript provides evidence that a type II PtdIns 4-kinase associates with p56(lck) in Con A stimulated rat splenic lymphocytes. In vitro phosphorylation studies suggest that p561(lck) regulates phosphorylation and activation of type II PtdIns 4-kinase. Inhibition of p561(lck) activity in vivo has shown to reduce tyrosyl phosphorylation and activation of PtdIns 4-kinase by Con A. These results suggest that p56(lck) may be the physiological regulator of type II PtdIns 4-kinase. (. .|
|Appears in Collections:||Article|
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